Separation of 1,4-benzodiazepine Derivates by Cyclodextrin Modified Micellar Electrokinetic Chromatography

Micellar Electrokinetic Capillary Chromatography of 1,4-Benzodiazepine Derivates and their Degradation Products

The aim of this work is to elaborate a fast and reliable capillary electrophoresis method, for the separation of 1,4-benzodiazepine (BZD) derivates and their degradation products in acidic medium and in UV light. Because BZDs are neutral, hydrophobic compounds, the most efficient method proved to be micellar elektrokinetic capillary chromatography (MECC). For the separation we used a sodium tet...

Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers

The applicability of micellar electrokinetic capillary chromatography (MEKC) for the separation of benzodiazepine (BZD) derivates with different structural characteristics has been studied. Efforts were first focused on the optimization of the analytical conditions, on the effects of buffer concentration, surfactant concentration and buffer pH on the separation. To manipulate selectivity of the...

Enantiomeric separation of primaquine, an anti-malarial drug, by cyclodextrin-modified micellar electrokinetic capillary chromatography.

Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.

A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation tempera...

A Comparative Study of the Separation of Oleanolic Acid and Ursolic Acid in Prunella vulgaris by High-Performance Liquid Chromatography and Cyclodextrin-Modified Micellar Electrokinetic Chromatography

A high-performance liquid chromatographic (HPLC) method and a cyclodextrin-modified micellar electrokinetic chromatographic (CD-MEKC) method were developed to separate and determine oleanolic acid (OA) and ursolic acid (UA) in Prunella vulgaris. HPLC separations were carried out on a Hedera ODS C18 column with methanol -H2Oacetic acid (85:15:0.3, v/v/v) as mobile phase at a flow-rate of 0.8 ml ...